We present the development of a new algorithm which combines state-of-the-art energy-dispersive x-ray (EDX) spectroscopy theory and a suitable machine learning formulation for the hyperspectral unmixing of scanning transmission electron microscope EDX spectrum images. The algorithm is based on non-negative matrix factorization (NMF) incorporating a physics-guided factorization model. ... https://www.roneverhart.com/HP-Victus-15L-TG02-0325m-Gaming-Desktop-AMD-Ryzen-7-5700G-3-8-GHz-Radeon-RX-6400-32GB-DDR4-1TB-SSD-Windows-11-Home-Mi/